ImmunologybioRxiv
PTPN22 R620W gene editing in T cells enhances low avidity TCR responses
W. Anderson, F. Barahmand-pour-Whitman, P. S. Linsley…·D. J. Rawlings
This study edits the PTPN22 R620W variant in T cells to show it enhances low avidity TCR responses, contributing to autoimmunity risk.
DOI 10.7554/elife.81577