Author

P. S. Linsley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Arnett· 1 shared A. F. Shamji· 1 shared B. Khor· 1 shared D. E. Levy· 1 shared D. J. Rawlings· 1 shared F. Barahmand-pour-Whitman· 1 shared I. J. Marie· 1 shared J. H. Buckner· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. Arnett

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

PTPN22 R620W gene editing in T cells enhances low avidity TCR responses

W. Anderson, F. Barahmand-pour-Whitman, P. S. Linsley, K. Cerosaletti, J. H. Buckner, D. J. Rawlings

This study edits the PTPN22 R620W variant in T cells to show it enhances low avidity TCR responses, contributing to autoimmunity risk.

bioRxiv · Jul 21, 2022Immunology

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

A. Arnett, K. G. Moo, K. J. Flynn, T. B. Sundberg, L. Johannessen, A. F. Shamji, N. S. Gray, T. Decker, V. H. Gersuk, D. E. Levy, I. J. Marie, Z. S. Rahman, Y. Zheng, P. S. Linsley, R. J. Xavier, B. Khor

The paper identifies DCA as a CDK8 inhibitor that induces a tolerogenic immunophenotype in CD4+ T cells through a novel CDK8-GATA3-FOXP3 pathway, promoting Treg and Th2 differentiation while inhibiting Th1 and Th17.

bioRxiv · Mar 4, 2021 · PreprintImmunology