Author

F. Brial

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:metabolomics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Magnan· 3 shared D. Gauguier· 3 shared A. Le Lay· 2 shared J. Chilloux· 2 shared J. K. Nicholson· 2 shared M. Lathrop· 2 shared M.-E. Dumas· 2 shared A. L. McCartney· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersPhysiology

C. Magnan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Improved Glucose Homeostasis Following Vertical Sleeve Gastrectomy is Associated with Alternate Wiring of the Liver Molecular Clock in a Rat Model of Spontaneously-Occurring Type 2 Diabetes

A. Le Lay, F. Brial, M. Lathrop, C. Magnan, D. Gauguier

This study shows that vertical sleeve gastrectomy alters the liver molecular clock in rats with type 2 diabetes, improving glucose homeostasis through changes in circadian rhythms and metabolism.

bioRxiv · Oct 9, 2023 · PreprintPhysiology

The Microbial Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function

F. Brial, F. Alzaid, K. Sonomura, K. Meneyrol, A. Le Lay, N. Pean, A. Neves, J. Chilloux, L. Hedjazi, T.-A. Sato, A. Rodriguez Martinez, N. Venteclef, J. K. Nicholson, C. Magnan, M. Lathrop, , D. Gauguier

This study identifies 4-cresol as a microbial metabolite that improves glucose homeostasis and β-cell function in preclinical models of cardiometabolic disease.

bioRxiv · Oct 16, 2018Physiology

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

L. Hoyles, M. L. Jimenez-Pranteda, J. Chilloux, F. Brial, A. Myridakis, T. Aranias, C. Magnan, G. R. Gibson, J. D. Sanderson, J. K. Nicholson, D. Gauguier, A. L. McCartney, M.-E. Dumas

The paper demonstrates that gut microbiota can convert trimethylamine N-oxide (TMAO) back to trimethylamine (TMA), which is then absorbed by the host and reconverted to TMAO, highlighting a metabolic retroconversion process.

bioRxiv · Mar 27, 2018Microbiology