The insulin / IGF axis is critically important for controlling gene transcription in the podocyte.
J. A. Hurcombe, L. Dayalan, F. Barrington, F. Burdet, L. Ni, J. T. Coward, M. Ibberson, P. Brinkkoetter, M. Holzenberger, A. R. Jeffries, S. Oltean, G. I. Welsh, R. J. Coward
This study shows that insulin/IGF1 signaling in podocytes regulates gene transcription by affecting spliceosome function and protein modifications.
bioRxiv · May 20, 2024Cell Biology