N. Hanna

Discovery of anti-infective compounds against Mycobacterium marinum after biotransformation of simple natural stilbene scaffolds by a fungal secretome

This study identifies trans-δ-viniferins as promising anti-infective scaffolds against Mycobacterium marinum using a Dictyostelium discoideum infection model and natural product derivatives.

ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer

This study identifies ADRA2A as a gene that promotes the classical/progenitor subtype and reduces aggressiveness in pancreatic cancer by altering transcriptome and metabolome profiles.

LMO3 is a suppressor of the basal-like/squamous PDAC subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism

This study identifies LMO3 as a suppressor of the aggressive basal-like/squamous PDAC subtype, showing it reduces disease aggressiveness through modulation of glycerol 3-phosphate metabolism.

Caspase-8 activity mediates TNFα production and restricts Coxiella burnetii replication during murine macrophage infection

This study investigates how caspase-8 regulates TNFα production and restricts Coxiella burnetii replication in macrophages during infection.

ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer

This study identifies ELAPOR1 as a tumor suppressor in pancreatic cancer, showing its association with reduced disease aggressiveness and a metabolic signature of the classical/progenitor subtype.

SERPINB3 induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

This study identifies SERPINB3 as a marker for the basal-like/squamous subtype of pancreatic cancer, showing it promotes invasion, metastasis, and metabolic reprogramming.

Temporal genome-wide fitness analysis of Mycobacterium marinum during infection reveals genetic requirement for virulence and survival in amoebae and microglial cells

This study uses Tn-Seq to identify essential genes for Mycobacterium marinum survival in amoebae and microglial cells, revealing metabolic and virulence gene requirements during infection.

Recognition of non-self is necessary to activate Drosophila's immune response against an insect parasite

The paper shows that Drosophila's immune response to parasitoid wasps requires both danger signals from wounding and a PAMP from the wasp to trigger melanization and Tep1 expression.

Disruption of vacuolin microdomains in the host Dictyostelium discoideum increases resistance to Mycobacterium marinum-induced membrane damage and infection

The paper shows that disrupting vacuolin microdomains in Dictyostelium discoideum reduces susceptibility to Mycobacterium marinum infection by impairing membrane damage and pathogen escape.

Dictyostelium discoideum flotillin homologues are essential for phagocytosis and participate in plasma membrane recycling and lysosome biogenesis

This study identifies vacuolins in Dictyostelium discoideum as functional homologues of flotillins, essential for phagocytosis, membrane recycling, and lysosome biogenesis.

Zinc intoxication of Mycobacterium marinum during Dictyostelium discoideum infection is counteracted by induction of the pathogen Zn2+ exporter CtpC

This study shows that M. marinum infection induces Zn2+ accumulation in D. discoideum phagosomes, which is counteracted by bacterial upregulation of the Zn2+ exporter CtpC.

Identification of novel anti-bacterial compounds from a chemically highly diverse pathways-based library using phenotypic screens in amoebae host models

This study screens a diverse chemical library in amoeba models to identify anti-bacterial compounds effective against M. marinum and L. pneumophila, finding 64 active compounds with varying efficacy.