Reticulocytes in donor RBC units enhance RBC alloimmunization
T. Thomas, A. Qiu, C. Y. Kim, D. E. Gordy, A. Miller, M. Tredicine, M. Dzieciatkowska, F. Dei Zotti, E. A. Hod, A. D'Alessandro, J. C. Zimring, S. L. Spitalnik, K. E. Hudson
This study shows that reticulocytes in donor RBC units increase alloimmunization rates in mice by enhancing alloantibody levels and proinflammatory responses.
bioRxiv · Jan 25, 2023 · PreprintImmunology