J. C. Zimring

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes

The paper identifies genetic polymorphisms and metabolite levels in stored red blood cells that correlate with hemolysis and transfusion outcomes.

IgG hexamers initiate acute lung injury

This study shows that IgG hexamerization is critical for triggering acute lung injury and suggests therapeutic strategies targeting hexamer formation.

Reticulocytes in donor RBC units enhance RBC alloimmunization

This study shows that reticulocytes in donor RBC units increase alloimmunization rates in mice by enhancing alloantibody levels and proinflammatory responses.

Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors

The paper identifies 423 genetic loci associated with 132 metabolites in red blood cells using a genome-wide association study of volunteer blood donors.

Innate and adaptive immunity to transfused allogenic red blood cells in mice requires MyD88

This study shows that MyD88, not TRIF, is required for DC activation and alloantibody response to stored syngeneic RBCs in mice.

Hematologic and systemic metabolic alterations due to Mediterranean type II G6PD deficiency in a novel murine model

This study creates a novel murine model of severe G6PD deficiency by introducing a human mutation, revealing metabolic alterations and hemolytic sequelae similar to humans.

The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality

This paper investigates the role of the N-terminus of band 3 in red blood cell metabolism and storage quality using genetic models and proteomic analyses, showing its impact on metabolic pathways and transfusion outcomes.