C. Y. Kim

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-Lck interactions

This study shows that CD4's GGXXG and (C/F)CV+C motifs are critical for pMHCII-specific signal amplification without requiring CD4-LCK interactions.

Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasion

This study identifies CD44 as a co-receptor used by Plasmodium falciparum for erythrocyte invasion, showing it enhances parasite entry through cytoskeletal protein phosphorylation.

Reticulocytes in donor RBC units enhance RBC alloimmunization

This study shows that reticulocytes in donor RBC units increase alloimmunization rates in mice by enhancing alloantibody levels and proinflammatory responses.

Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum

This study uses cryogenic electron tomography to reveal new structural details of the apical complex in Plasmodium falciparum merozoites, including interactions between rhoptries and other structures.

Coupling cryo-electron tomography with mixed-scale dense neural networks reveals re-organization of the invasion machinery of Toxoplasma gondii upon ionophore-stimulation

The paper uses cryo-electron tomography and mixed-scale dense neural networks to analyze the reorganization of Toxoplasma gondii's invasion machinery upon ionophore stimulation, revealing structural changes and evolutionary conservation with Plasmodium falciparum.

Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY

This study identifies a proton exchange-based isomerization and lactonization mechanism in the plant enzyme COSY, revealing its unique catalytic activity and evolutionary adaptation.

The TCR Cα domain regulates responses to self-pMHCII

This study investigates the role of the TCR Cα domain in regulating CD4+ T cell responses to self-pMHCII, finding that mutations in this domain increase tonic signaling and homeostatic survival without affecting proliferation or differentiation.

Adolescent parvalbumin expression in the left orbitofrontal cortex shapes sociability in female mice

This study shows that adolescent social isolation in female mice leads to increased sociability, reduced parvalbumin expression, and decreased social sniffing activity in the left orbitofrontal cortex, highlighting the role of PV+ inhibitory circuits in shaping female social behavior.

HiFi Metagenomic Sequencing Enables Assembly of Accurate and Complete Genomes from Human Gut Microbiota

This study uses HiFi metagenomic sequencing to assemble 102 complete MAGs from human fecal samples, achieving high nucleotide accuracy and capturing previously unculturable microbial genomes.

MRGM: a mouse reference gut microbiome reveals a large functional discrepancy for gut bacteria of the same genus between mice and humans

The paper constructs a mouse reference gut microbiome (MRGM) and finds significant functional discrepancies between mouse and human gut bacteria of the same genus.

Human reference gut microbiome comprising 5,414 prokaryotic species, including newly assembled genomes from under-represented Asian metagenomes

The paper expands the human gut microbiome reference database by incorporating newly assembled genomes from under-represented Asian populations, improving taxonomic and functional classification and revealing associations with autoimmunity.

A Dual Reward-Place Association Task to Study the Preferential Retention of relevant Memories in Rats

This paper introduces a dual reward-place association task in rats to study how memory retention depends on reward magnitude and spatial integration.