Molecular mechanism of Arp2/3 complex inhibition by Arpin
F. E. Fregoso, T. van Eeuwen, G. Simanov, G. Rebowski, M. Boczkowska, A. Zimmet, A. M. Gautreau, R. Dominguez
This study determines the cryo-EM structure of Arpin bound to Arp2/3 complex and identifies sequence differences in the C-helix that distinguish inhibition from activation.
bioRxiv · Oct 30, 2021Biochemistry