Author

G. Simanov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:clustering· 1 Assay:cryo-EM· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. M. Gautreau· 3 shared A. I. Fokin· 2 shared A. Boutillon· 1 shared A. Polesskaya· 1 shared A. Zimmet· 1 shared F. E. Fregoso· 1 shared G. Rebowski· 1 shared I. Bieche· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

A. M. Gautreau

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Inactivating Negative Regulators of Cortical Branched Actin Enhances Persistence of Single Cell Migration

A. I. Fokin, A. Boutillon, J. James, L. Courtois, S. Vacher, G. Simanov, Y. Wang, A. Polesskaya, I. Bieche, N. B. David, A. M. Gautreau

The paper shows that inactivating three negative regulators of cortical branched actin enhances migration persistence in human and zebrafish cells, with vimentin down-regulation contributing to the stable maintenance of this phenotype.

bioRxiv · May 13, 2023Cell Biology

Molecular mechanism of Arp2/3 complex inhibition by Arpin

F. E. Fregoso, T. van Eeuwen, G. Simanov, G. Rebowski, M. Boczkowska, A. Zimmet, A. M. Gautreau, R. Dominguez

This study determines the cryo-EM structure of Arpin bound to Arp2/3 complex and identifies sequence differences in the C-helix that distinguish inhibition from activation.

bioRxiv · Oct 30, 2021Biochemistry

Arpin regulates migration persistence by interacting with both tankyrases and the Arp2/3 complex

G. Simanov, I. Dang, A. I. Fokin, K. Oguievetskaia, V. Campanacci, J. Cherfils, A. M. Gautreau

This study identifies Arpin's interacting partners, showing it regulates migration persistence through two independent pathways involving Tankyrase and Arp2/3.

bioRxiv · Mar 16, 2021Cell Biology