R. Dominguez

Myosin-I Synergizes with Arp2/3 Complex to Enhance Pushing Forces of Branched Actin Networks

This study shows myosin-I enhances the force generation of Arp2/3 complex-nucleated actin networks by thinning them and promoting symmetry breaking.

Molecular mechanism of Arp2/3 complex inhibition by Arpin

This study determines the cryo-EM structure of Arpin bound to Arp2/3 complex and identifies sequence differences in the C-helix that distinguish inhibition from activation.

Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway

The paper identifies sequential dynein effector handoffs during axonal autophagosome transport and maturation, showing their role in motility and neuronal health.

Novel human cell expression method reveals the role and prevalence of posttranslational modification in non-muscle tropomyosins

The paper introduces a human cell expression method that enables the production of non-muscle tropomyosins with native termini and PTMs, showing functional differences from bacterial-expressed versions.

Rickettsia Sca2 Recruits Two Actin Subunits for Nucleation but Lacks WH2 Domains

This paper identifies Sca2 as an actin nucleator that binds two actin monomers without WH2 domains, revealing a novel mechanism distinct from eukaryotic formins.

Mechanism of IRSp53 inhibition by 14-3-3

The paper identifies how 14-3-3 inhibits IRSp53 through phosphorylation, counteracting Cdc42-mediated activation in filopodia dynamics.