Global Increases in Human Immunodeficiency Virus Neutralization Sensitivity Due to Alterations in the Membrane-Proximal External Region of the Envelope Glycoprotein Can be Minimized by Distant State 1-Stabilizing Changes
Q. Wang, F. Esnault, M. Zhao, T.-J. Chiu, A. B. Smith, H. T. Nguyen, J. G. Sodroski
The paper shows that changes in the MPER of HIV-1 Env lead to premature triggering and increased neutralization sensitivity, which can be counteracted by distant State 1-stabilizing Env modifications.
bioRxiv · Nov 1, 2021Microbiology