Author

T.-J. Chiu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. B. Smith· 4 shared J. G. Sodroski· 3 shared N. Madani· 3 shared S. Anang· 3 shared A. Finzi· 2 shared C. Bourassa· 2 shared H.-C. Chen· 2 shared J. Richard· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersMicrobiology

A. B. Smith

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Author profile →

4 papers

Recent·Most cited

V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins

S. Anang, S. Zhang, C. Fritschi, T.-J. Chiu, A. B. Smith, N. Madani, J. G. Sodroski

This study identifies residue changes in the gp120 V3 loop that influence susceptibility of HIV-1 Envs to CD4-mimetic compounds, showing how variations outside the binding site affect inhibitor sensitivity.

bioRxiv · Jul 31, 2023Microbiology

Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

C. J. Fritschi, S. Anang, Z. Gong, M. Mohammadi, J. Richard, C. Bourassa, K. T. Severino, H. Richter, D. Yang, H.-C. Chen, T.-J. Chiu, M. Seaman, N. Madani, C. Abrams, A. Finzi, , A. B. Smith

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

bioRxiv · Jan 2, 2023 · PreprintMicrobiology

Characterization of human immunodeficiency virus (HIV-1) envelope glycoprotein variants selected for resistance to a CD4-mimetic compound

S. Anang, J. Richard, C. Bourassa, G. Goyette, T.-J. Chiu, H.-C. Chen, A. B. Smith, N. Madani, A. Finzi, J. G. Sodroski

This study identifies HIV-1 Env variants resistant to CD4-mimetic compounds and BMS-806 by analyzing mutations that confer resistance and their effects on viral fitness and inhibitor sensitivity.

bioRxiv · Apr 21, 2022Microbiology

Global Increases in Human Immunodeficiency Virus Neutralization Sensitivity Due to Alterations in the Membrane-Proximal External Region of the Envelope Glycoprotein Can be Minimized by Distant State 1-Stabilizing Changes

Q. Wang, F. Esnault, M. Zhao, T.-J. Chiu, A. B. Smith, H. T. Nguyen, J. G. Sodroski

The paper shows that changes in the MPER of HIV-1 Env lead to premature triggering and increased neutralization sensitivity, which can be counteracted by distant State 1-stabilizing Env modifications.

bioRxiv · Nov 1, 2021Microbiology