J. G. Sodroski

The paper shows that expressing broadly or poorly neutralizing antibodies or CD4 in HIV-1-producing cells reduces viral infectivity by disrupting Env processing and incorporation into virions.

This study identifies residue changes in the gp120 V3 loop that influence susceptibility of HIV-1 Envs to CD4-mimetic compounds, showing how variations outside the binding site affect inhibitor sensitivity.

This study compares the stability and conformation of HIV-1 Env in detergents versus SMA lipids, showing SMA preserves the pretriggered state better at room temperature.

This paper characterizes HIV-1 Env conformational states on virions and shows how stabilizing the pretriggered State-1 conformation enhances bNAb recognition and reduces shedding.

This study identifies HIV-1 Env variants resistant to CD4-mimetic compounds and BMS-806 by analyzing mutations that confer resistance and their effects on viral fitness and inhibitor sensitivity.

This study compares the functional properties of the B.1.1.529 SARS-CoV-2 spike glycoprotein with previous variants, finding reduced processing and lower stability but equivalent infection efficiency and increased ACE2 binding affinity.

The paper shows that changes in the MPER of HIV-1 Env lead to premature triggering and increased neutralization sensitivity, which can be counteracted by distant State 1-stabilizing Env modifications.

This study identifies key features of the SARS-CoV-2 spike glycoprotein, including the furin cleavage site and D614G mutation, that influence viral infectivity, stability, and cytopathicity.

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.