Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state
A.-M. Cao, R. B. Quast, F. Fatemi, P. Rondard, J.-P. Pin, E. Margeat
This study shows that positive allosteric modulators stabilize the active state of mGlu2, enhancing agonist efficacy by increasing its residence time in the active conformation.
bioRxiv · Jan 5, 2021Biophysics