Author

R. B. Quast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

E. Margeat· 3 shared F. Fatemi· 2 shared J.-P. Pin· 2 shared P. Rondard· 2 shared A.-M. Cao· 1 shared E. Trinquet· 1 shared G. Truan· 1 shared H. Liu· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiophysics

E. Margeat

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Dissecting conformational rearrangements and allosteric modulation in metabotropic glutamate receptor activation

N. Lecat-Guillet, R. B. Quast, H. Liu, T. C. Moller, X. Rovira, S. Soldevilla, L. Lamarque, E. Trinquet, J. Liu, J.-P. Pin, P. Rondard, E. Margeat

The paper uses FRET sensors to study conformational changes in mGlu2 receptors, showing ligands modulate activation through multiple states.

bioRxiv · Jan 7, 2022 · PreprintBiophysics

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

A.-M. Cao, R. B. Quast, F. Fatemi, P. Rondard, J.-P. Pin, E. Margeat

This study shows that positive allosteric modulators stabilize the active state of mGlu2, enhancing agonist efficacy by increasing its residence time in the active conformation.

bioRxiv · Jan 5, 2021Biophysics

Accurate Determination of Human CPR Conformational Equilibrium by smFRET using Dual Orthogonal Non-Canonical Amino Acid Labeling

R. B. Quast, F. Fatemi, M. Kranendonk, E. Margeat, G. Truan

The paper develops a method to accurately determine conformational equilibrium of CPR using smFRET with non-canonical amino acid labeling and demonstrates its application to study NADP+ effects.

bioRxiv · Sep 10, 2018Biochemistry