Author

E. Margeat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:fluorescence / live-cell microscopy· 4 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:E. coli· 1

Frequent Co-Authors

R. B. Quast· 3 shared F. Fatemi· 2 shared J.-P. Pin· 2 shared P. Rondard· 2 shared A. Barth· 1 shared A. Damm· 1 shared A. Di Cicco· 1 shared A. Hartmann· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiophysics

R. B. Quast

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Conformational changes of the ABC Transporter BmrA Depend on Membrane Curvature

A. Damm, K. Belhadji, R. K. Sadhu, S.-J. Paik, A. Di Cicco, J. Manzi, M. Castellana, R. Regmi, E. Margeat, M. Dahan, P. Sens, D. Levy, P. Bassereau

This study shows that the conformational changes of the bacterial ABC transporter BmrA are influenced by membrane curvature, affecting its activity and conformational states.

bioRxiv · Jan 24, 2024 · PreprintBiophysics

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

G. Agam, C. Gebhardt, M. Popara, R. Maechtel, J. Folz, B. Ambrose, N. Chamachi, S. Y. Chung, T. D. Craggs, M. de Boer, D. Grohmann, T. Ha, A. Hartmann, J. Hendrix, V. Hirschfeld, , T. Cordes

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

bioRxiv · Aug 3, 2022Biophysics

Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from Streptococcus pneumoniae.

M. Hertzog, T. N. Perry, P. Dupaigne, S. Serres, V. Morales, A.-L. Soulet, J. Bell, E. Margeat, S. C. Kowalczykowski, E. Le Cam, R. Fronzes, P. Polard

This study characterizes the ATP-dependent assembly mechanism and cryoEM structure of RecA nucleofilaments from Streptococcus pneumoniae, revealing differences in ssDNA binding and HR activity compared to Escherichia coli.

bioRxiv · Jul 28, 2022 · PreprintMicrobiology

Dissecting conformational rearrangements and allosteric modulation in metabotropic glutamate receptor activation

N. Lecat-Guillet, R. B. Quast, H. Liu, T. C. Moller, X. Rovira, S. Soldevilla, L. Lamarque, E. Trinquet, J. Liu, J.-P. Pin, P. Rondard, E. Margeat

The paper uses FRET sensors to study conformational changes in mGlu2 receptors, showing ligands modulate activation through multiple states.

bioRxiv · Jan 7, 2022 · PreprintBiophysics

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

A.-M. Cao, R. B. Quast, F. Fatemi, P. Rondard, J.-P. Pin, E. Margeat

This study shows that positive allosteric modulators stabilize the active state of mGlu2, enhancing agonist efficacy by increasing its residence time in the active conformation.

bioRxiv · Jan 5, 2021Biophysics

Accurate Determination of Human CPR Conformational Equilibrium by smFRET using Dual Orthogonal Non-Canonical Amino Acid Labeling

R. B. Quast, F. Fatemi, M. Kranendonk, E. Margeat, G. Truan

The paper develops a method to accurately determine conformational equilibrium of CPR using smFRET with non-canonical amino acid labeling and demonstrates its application to study NADP+ effects.

bioRxiv · Sep 10, 2018Biochemistry