Endogenous TDP-43 prevents retrotransposons activation through Dicer-2 activity and the RNA silencing machinery in Drosophila
F. Feiguin, G. Romano, R. Klima
This study shows TDP-43 prevents retrotransposon activation in Drosophila by modulating Dicer-2 and the RNA silencing pathway, reducing neurodegeneration.
bioRxiv · Apr 10, 2019 · PreprintCell Biology