R. Klima

Drug-repurposing screen identifies thiostrepton as a novel regulator of the tumor suppressor DAB2IP

The paper screens FDA-approved drugs to find those that increase DAB2IP protein levels, identifying thiostrepton as a potential anti-cancer agent that relies on DAB2IP for its tumor-suppressive effect.

Endogenous TDP-43 prevents retrotransposons activation through Dicer-2 activity and the RNA silencing machinery in Drosophila

This study shows TDP-43 prevents retrotransposon activation in Drosophila by modulating Dicer-2 and the RNA silencing pathway, reducing neurodegeneration.