Nitric oxide S-nitrosylates CSF1R to augment the action 1 of CSF1R inhibition against castration resistant prostate cancer
M. Kuchakulla, F. FIRDAUS, R. QURESHI, Y. SONI, D. Van Booven, K. SHAH, R. A. Dulce, T. Masterson, O. J. Rosete, J. M. Hare, R. RAMASAMY, H. ARORA
This study shows that nitric oxide enhances the effectiveness of CSF1R inhibition in castration-resistant prostate cancer by promoting S-nitrosylation of CSF1R, improving tumor suppression and immune response.
bioRxiv · Jun 9, 2022 · PreprintCancer Biology