K. Shah

2.5D Actuating Substrates Enable Decoupling the Mechanical and Biochemical Effects of Muscle Exercise on Motor Neurons

This study uses 2.5D actuating substrates to show that both mechanical and biochemical effects of muscle exercise significantly influence motor neuron growth and maturation.

Identifying the genetic and epigenetic basis for asymmetric bZIP expression in temperature-stressed bread wheat

This study investigates the genetic and epigenetic factors underlying asymmetric bZIP expression in bread wheat under temperature stress.

Exosome derived multi-gene biomarker panel identifies the risk of liver metastasis in lung cancer patients

The paper identifies a 5-gene exosomal biomarker panel with high accuracy for predicting liver metastasis in lung cancer patients.

Concatenated Modular BK Channel Constructs Reveal Divergent Stoichiometry in Gating Control by LRRC26 (γ1), Pore, and Selectivity Filter

The paper develops concatenated BK channel constructs to study subunit stoichiometry in gating, finding distinct stoichiometric effects of LRRC26, pore, and selectivity filter mutations.

Dopamine functionalized, red carbon quantum dots for in vivo bioimaging, cancer therapeutics, and neuronal differentiation

This paper develops dopamine-functionalized carbon quantum dots for bioimaging, cancer therapy, and neuronal differentiation using mango leaf extract.

Dietary environmental factors shape the immune defence against infection with Cryptosporidium

The paper shows that dietary metabolites enhance CD8+ T-cell immunity against Cryptosporidium infection in mice by activating the AHR pathway.

Immunoreactivity against SLC3A2 in high grade gliomas displays positive correlation with glioblastoma patient survival: Potential target for glioma diagnosis and therapy

The paper identifies SLC3A2 as an autoantigen in high-grade gliomas, showing its immunoreactivity correlates with improved patient survival.

Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer

The paper identifies lymphoproliferative B cells in NSCLC PDX models and develops a tool for generating pathology overview figures.

S-nitrosoglutathione Inhibits the Growth of Androgen-Receptor Dependent and Castration Resistant Prostate Cancer by Modulating FOXM1 Signaling

This study identifies GSNO as a nitric oxide donor that inhibits CRPC growth by targeting FOXM1, regardless of AR status.

Novel class of yellow emitting carbon dots stimulate collective cell migration and 3D uptake in vivo

The paper presents nitrogen-doped yellow fluorescent carbon dots with stable fluorescence and efficient uptake by mammalian cells and zebrafish larvae, showing potential for bioimaging and biomedical applications.

Nitric oxide S-nitrosylates CSF1R to augment the action 1 of CSF1R inhibition against castration resistant prostate cancer

This study shows that nitric oxide enhances the effectiveness of CSF1R inhibition in castration-resistant prostate cancer by promoting S-nitrosylation of CSF1R, improving tumor suppression and immune response.

Green emitting carbon quantum dots (GCQDs) to probe endocytic pathways in cells; for tissue and in vivo bioimaging

This study synthesizes green emitting carbon quantum dots (GCQDs) for in vitro and in vivo bioimaging, showing their uptake via clathrin-mediated pathways in mouse cells and zebrafish embryos.

Decrowding Expansion Pathology: Unmasking Previously Invisible Nanostructures and Cells in Intact Human Brain Pathology Specimens

The paper introduces dExPath, an expansion microscopy variant that improves immunostaining in human brain pathology specimens by expanding proteins and reducing autofluorescence, revealing previously invisible disease markers.

Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation

This study identifies eosinophils as critical regulators of intestinal homeostasis, barrier integrity, and motility following microbial colonization.

NOVEL NUCLEAR ROLE OF HDAC6 IN PROGNOSIS AND THERAPEUTIC TARGET FOR COLORECTAL CANCER

This study identifies a novel nuclear role of HDAC6 in colorectal cancer prognosis and therapy, showing its association with chromatin relaxation, gene expression, and synergistic effects with DNA damaging agents.

Mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis

This study identifies mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis through in vitro and in vivo experiments.

BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma

This study shows BAP1 and YY1 suppress TRAIL receptor expression in MPM, making them potential targets to enhance TRAIL therapy.

Super-human cell death detection with biomarker-optimized neural networks

This paper introduces BO-CNN, a neural network that detects cell death in live microscopy with 96% accuracy, faster than previous methods and without requiring stains or dyes.

Resolvin D-series regulates Phospholipase D both during inflammation and resolution by modulating phagocyte functions

This study shows that D-series resolvins regulate phospholipase D2 to modulate macrophage polarization and resolution of inflammation.

Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression

The paper identifies fibroblast-expressed PIK3Cδ as a key driver of triple-negative breast cancer progression through paracrine signaling and shows its prognostic significance.

Androgen Receptor Signaling Regulates the Transcriptome of Prostate Cancer Cells by Modulating Global Alternative Splicing

This study shows that androgen receptor signaling in prostate cancer cells regulates alternative splicing of genes, contributing to tumor progression and resistance to anti-androgen therapies.

Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth

The paper develops DPY30-targeting peptides that inhibit blood cancer cell growth by disrupting ASH2L binding and H3K4 methylation.