Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin
F. J. Garcia-Rodriguez, C. Martinez-Fernandez, D. Brena, E. Nadal, M. Boxem, S. Honnen, A. Miranda-Vizuete, A. Villanueva, J. Ceron
This study investigates cisplatin sensitivity in C. elegans, identifying factors like DAF-16/FOXO, SKN-1/Nrf2, and the intrinsic apoptotic pathway, and discovers a resistance mechanism involving trxr-1 and selenocysteine.
bioRxiv · Dec 12, 2017Cancer Biology