Author

F. J. Giles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. D. Louie· 1 shared B. A. Carneiro· 1 shared B. Borden· 1 shared C. Schorl· 1 shared D. Newhouse· 1 shared D. Silverberg· 1 shared J. F. Anker· 1 shared K. E. Huntington· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. D. Louie

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2 papers

Recent·Most cited

GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer

K. E. Huntington, A. D. Louie, P. Srinivasan, C. Schorl, S. Lu, D. Silverberg, D. Newhouse, Z. Wu, L. Zhou, B. Borden, F. J. Giles, M. Dooner, B. A. Carneiro, W. S. El-Deiry

This study shows that elraglusib enhances immune cell activation and synergizes with anti-PD-L1 in a murine colorectal cancer model, with clinical implications for combination immunotherapy.

bioRxiv · Feb 7, 2023Cancer Biology

Landscape of tumor-infiltrating immune cells in human immunogenic cancers: B cells are inversely associated with CD8T cells, but positively correlated with Treg cells

Y. K. Chae, W. Bae, M. Jung, Y. S. Kim, J. F. Anker, K. Tamragouri, M. Matsangou, F. J. Giles

The paper analyzes immune cell infiltration in six cancers, finding activated B cells correlate with reduced CD8 T cell infiltration and increased Treg cells, suggesting B cells may inhibit T cell activity.

bioRxiv · May 17, 2019 · PreprintCancer Biology