Y. S. Kim

A human pluripotent stem cell-based somitogenesis model using microfluidics

This study develops a microfluidic hPSC-based model to control biochemical and biomechanical signals during somitogenesis, revealing their roles in somite formation.

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

Functional immune state classification of unlabeled live human monocytes using holotomography and machine learning

This study uses holotomography and machine learning to classify functional immune states of human monocytes, achieving high accuracy in identifying hyper-inflammatory and immune-suppressed states.

Volumetric refractive index measurement and quantitative density analysis of mouse brain tissue with sub-micrometer spatial resolution

This paper presents a label-free method for high-resolution volumetric imaging and analysis of mouse brain tissue with sub-micrometer spatial resolution.

Structural basis for ion selectivity in potassium-selective channelrhodopsins

The paper determines the cryo-EM structures of two K+-selective channelrhodopsins, revealing a unique mechanism for K+ selectivity distinct from canonical K+ channels.

Pentoxifylline-induced Protein Expression Change in RAW 264.7 Cells as Determined by Immunoprecipitation-based High Performance Liquid Chromatography

This study examines the differential effects of low and high doses of pentoxifylline on RAW 264.7 cells using IP-HPLC, showing distinct impacts on proliferation, inflammation, and differentiation.

Overexpression of NDR1 Leads to Pathogen Resistance at Elevated Temperatures

The paper shows NDR1 overexpression enhances pathogen resistance at elevated temperatures by maintaining immune signaling during ETI.

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage independence

This study shows that HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage independence in ovarian cancer cells.

Viperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway

This study shows viperin reduces cholesterol levels by inhibiting key enzymes in the biosynthetic pathway, though the exact mechanism remains unclear.

cytoNet: Spatiotemporal Network Analysis of Cell Communities

cytoNet analyzes cell communities in microscopy images to quantify spatial relationships and functional interactions, demonstrating applications in neuroscience and tissue biology.

Data-driven multiplexed microtomography of endogenous subcellular dynamics

This paper introduces a data-driven method for multiplexed microtomography using refractive index imaging to study endogenous subcellular dynamics without exogenous labels.

Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice

This paper develops a DNA vaccine encoding SFTSV antigens and adjuvants that provides complete protection in IFNAR knockout mice, while protein antigens alone fail to do so.

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.

This study shows that SIRT3 activation is required for ovarian cancer cell survival and metastasis by regulating mitochondrial antioxidant defenses and metabolic changes during detachment.

Landscape of tumor-infiltrating immune cells in human immunogenic cancers: B cells are inversely associated with CD8T cells, but positively correlated with Treg cells

The paper analyzes immune cell infiltration in six cancers, finding activated B cells correlate with reduced CD8 T cell infiltration and increased Treg cells, suggesting B cells may inhibit T cell activity.