Author

P. Srinivasan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. D. Louie· 2 shared K. E. Huntington· 2 shared L. Zhou· 2 shared W. S. El-Deiry· 2 shared X.-P. Wang· 2 shared A. A. Seyhan· 1 shared A. De La Cruz· 1 shared A. E. Abbas· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPathology

A. D. Louie

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Varying selection pressure for a Na+ sensing site in epithelial Na+ channel subunits reflect divergent roles in Na+ homeostasis

X.-P. Wang, P. Srinivasan, M. El Hamdaoui, R. Grytz, O. Kashlan

The paper examines the evolution of a Na+ binding site in ENaC subunits, showing that the site is conserved in subunits but lost in delta subunits, suggesting divergent roles in Na+ homeostasis.

bioRxiv · Feb 16, 2024Evolutionary Biology

Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion

D. Anaguano, O. Adewale Fasoro, G. S. Vick, J. A. Blauwkamp, S. Yanik, M. A. Fierro, S. Absalon, P. SRINIVASAN, V. Muralidharan

This study shows that RON11 is essential for the biogenesis of the second rhoptry in Plasmodium falciparum merozoites and is required for erythrocyte invasion.

bioRxiv · Jan 29, 2024Cell Biology

Mineralocorticoid receptor-independent activation of ENaC in bile duct ligated mice

X.-P. Wang, S. M. Mutchler, R. Carrisoza-Gaytan, M. Al-bataineh, C. J. Baty, A. Vandevender, P. Srinivasan, R. J. Tan, M. J. Jurczak, L. M. Satlin, O. B. Kashlan

This study shows that bile acid elevation in liver disease activates ENaC and causes fluid retention independently of RAAS, offering new therapeutic targets.

bioRxiv · Sep 19, 2023Physiology

TRAIL agonists rescue mice from radiation-induced lung injury

J. Strandberg, A. D. Louie, S. Lee, M. Hahn, P. Srinivasan, A. George, A. De La Cruz, L. Zhang, L. H. Borrero, K. E. Huntington, P. De La Cruz, A. A. Seyhan, P. P. Koffer, D. E. Wazer, T. A. DiPetrillo, , W. S. El-Deiry

TRAIL agonists reduce radiation-induced lung injury and lethality in mice by inhibiting CCl22 and improving pneumonitis, alveolar-wall thickness, and oxygen desaturation.

bioRxiv · Jun 12, 2023 · PreprintPathology

GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer

K. E. Huntington, A. D. Louie, P. Srinivasan, C. Schorl, S. Lu, D. Silverberg, D. Newhouse, Z. Wu, L. Zhou, B. Borden, F. J. Giles, M. Dooner, B. A. Carneiro, W. S. El-Deiry

This study shows that elraglusib enhances immune cell activation and synergizes with anti-PD-L1 in a murine colorectal cancer model, with clinical implications for combination immunotherapy.

bioRxiv · Feb 7, 2023Cancer Biology

Doublecortin like kinase 1 is a target in squamous cell carcinoma

D. Standing, L. Arnold, P. Dandawate, B. Ottemann, V. Snyder, S. Ponnurangam, D. Subramaniam, P. Srinivasan, S. Choudhury, J. New, D. Kwatra, P. Ramamoorthy, B. C. Roy, M. Shadoin, R. Al-Rajabi, , S. M. Thomas

This study identifies DCLK1 as a critical target in squamous cell carcinoma, showing its role in tumor growth and demonstrating a selective inhibitor, DiFiD, that suppresses cancer progression.

bioRxiv · May 26, 2022Cancer Biology

Chlorine inactivation of Escherichia coli O157:H7 in fresh produce wash process: effectiveness and modeling

M. D. Abnavi, C. Kothapalli, D. Munther, P. Srinivasan

This study develops a model to assess how organic content affects chlorine's ability to inactivate E. coli O157:H7 in fresh produce washes, finding a significant reduction in efficacy with organic load.

bioRxiv · Feb 12, 2021Microbiology