Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes
F. J. Lewis, D. Chatterjee, J. Kaczmarski, X. Gao, Y. Cai, H. A. McNamara, H. J. Sutton, C. J. Jackson, I. A. Cockburn
The paper shows that B cells avidly bind to the Plasmodium CSP repeat domain, suppressing responses to protective epitopes, and that truncated CSP molecules induce broader immune responses and better protection.
bioRxiv · Jan 12, 2020Immunology