Author

I. A. Cockburn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 13

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Organism:mouse· 11 Approach:experimental assay· 9 Research Focus:cell type annotation· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:imaging· 3 Assay:proteomics· 3

Frequent Co-Authors

H. J. Sutton· 6 shared V. V. Ganusov· 5 shared Y. Cai· 5 shared H. A. McNamara· 4 shared X. Gao· 4 shared A. H. Idris· 3 shared D. Chatterjee· 3 shared R. A. Seder· 3 shared

Activity by Year

2017-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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6 shared papersImmunology

H. J. Sutton

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Author profile →

13 papers

Recent·Most cited

Plasma cells are formed in waning germinal centers via an affinity-independent process

H. J. Sutton, B. J. Parker, M. Lofgren, C. Dacon, D. Chatterjee, X. Gao, H. G. Kelly, R. A. Seder, J. Tan, A. H. Idris, T. Neeman, I. A. Cockburn

The paper tracks Ighg2A10 cells in germinal centers using single-cell RNA-seq and finds that plasma cells form in waning GCs through an affinity-independent process.

bioRxiv · Apr 13, 2023 · PreprintImmunology

ZEB2 regulates the development of CD11c+ atypical B cells

X. Gao, Q. Shen, J. A. Roco, K. Frith, C. M. L. Munier, M. Nekrasov, B. Dalton, J.-S. He, R. Jaeger, M. C. Cook, J. J. Zaunders, I. A. Cockburn

The paper identifies ZEB2 as a key transcription factor regulating the development of CD11c+ atypical B cells in both mice and humans.

bioRxiv · Sep 1, 2022Immunology

Need for CD8 T cell clusters to eliminate a malaria liver stage arises in part due to heterogeneity in killing efficacy of individual effector T cells

S. Bera, R. Amino, I. A. Cockburn, V. V. Ganusov

The paper uses intravital microscopy to analyze CD8 T cell clusters and their killing efficacy against malaria liver-stage parasites, finding significant variability in parasite elimination.

bioRxiv · May 18, 2022Immunology

Platelets are dispensable for the ability of CD8+ T cells to accumulate, patrol, kill and reside in the liver

J. H. O'Connor, H. A. McNamara, Y. Cai, L. A. Coupland, E. E. Gardiner, C. R. Parish, B. J. McMorran, V. V. Ganusov, I. A. Cockburn

This study shows that platelets are not essential for CD8+ T cell accumulation, patrolling, killing, and residency in the liver, while ASGP-expressing cells are retained in the liver but lost from the spleen.

bioRxiv · Nov 9, 2021 · PreprintImmunology

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

B. Boast, K. Helian, D. Andrews, X. Li, V. Cho, A. Closa, H. J. Sutton, J. H. Reed, H. Bergmann, C. M. Roots, M. Yabas, N. Barthel, S. A. Omari, C. Young, L. A. Miosge, , A. Enders

Reduced PAX5 function in mice leads to uncommitted B cell development and B-ALL with secondary mutations in Jak3 and Ptpn11.

bioRxiv · Jan 29, 2021 · PreprintImmunology

A new method based on the von Mises-Fisher distribution shows that a minority of liver-localized CD8 T cells display hard-to-detect attraction to Plasmodium-infected hepatocytes

V. S. Zenkov, J. O'Connor, I. A. Cockburn, V. V. Ganusov

The paper introduces a method using the von Mises-Fisher distribution to analyze T cell attraction to Plasmodium-infected hepatocytes, finding that most liver-localized CD8 T cells search randomly while a minority show weak attraction.

bioRxiv · Dec 12, 2020Immunology

Liver environment-imposed constraints diversify movement strategies of liver-localized CD8 T cells

H. Rajakaruna, J. O'Connor, I. A. Cockburn, V. V. Ganusov

This study quantifies movement patterns of liver-localized CD8 T cells in mice, showing they perform correlated random walks and Levy flights influenced by liver structure and physiology.

bioRxiv · Nov 6, 2020Immunology

PD-L1hi plasmablasts limit the T cell response during the acute phase of parasite infections

M. Gorosito Serran, F. Fiocca Vernengo, L. Almada, C. G. Beccaria, P. F. Canete, J. Rocco Alegre, J. Tosello Boari, M. C. Ramello, E. Wehrens, Y. Cai, E. I. Zuniga, C. L. Montes, E. V. Acosta Rodriguez, I. A. Cockburn, C. G. Vinuesa, A. Gruppi

The paper identifies PD-L1hi plasmablasts that suppress T cell responses during acute parasite infections.

bioRxiv · Jun 10, 2020 · PreprintImmunology

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

H. J. Sutton, R. Aye, A. H. Idris, R. Vistein, E. Nduati, O. Kai, J. Mwacharo, L. Xi, X. Gao, D. Andrews, M. Koutsakos, T. H. O. Nguyen, M. Nekrasov, P. Milburn, A. Ethala, , I. A. Cockburn

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

bioRxiv · May 28, 2020 · PreprintImmunology

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

F. J. Lewis, D. Chatterjee, J. Kaczmarski, X. Gao, Y. Cai, H. A. McNamara, H. J. Sutton, C. J. Jackson, I. A. Cockburn

The paper shows that B cells avidly bind to the Plasmodium CSP repeat domain, suppressing responses to protective epitopes, and that truncated CSP molecules induce broader immune responses and better protection.

bioRxiv · Jan 12, 2020Immunology

Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses

H. A. McNamara, A. H. Idris, H. J. Sutton, B. J. Flynn, Y. Cai, K. Wiehe, K. E. Lyke, D. Chatterjee, N. KC, S. Chakravarty, K. L. Sim, S. L. Hoffman, M. Bonsignori, R. A. Seder, I. A. Cockburn

The paper shows antibody feedback limits memory B cell expansion but allows diversification of vaccine-induced antibody responses by suppressing dominant epitopes while enabling subdominant ones.

bioRxiv · Oct 18, 2019 · PreprintImmunology

Clustering of activated CD8 T cells around malaria-infected hepatocytes is rapid and is driven by antigen-specific T cells

R. Kelemen, H. Rajakaruna, I. A. Cockburn, V. V. Ganusov

bioRxiv · May 31, 2019Immunology

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

C. R. Fisher, H. J. Sutton, J. A. Kaczmarski, H. A. McNamara, B. Clifton, J. Mitchell, Y. Cai, J. N. Dups, N. J. D'Arcy, M. Singh, A. Chuah, T. Peat, C. J. Jackson, I. A. Cockburn

The paper investigates how T-dependent B cells produce antibodies that form a high-avidity multivalent complex with Plasmodium falciparum CSP, revealing structural and immunological insights.

bioRxiv · Jun 13, 2017Immunology