Author

H. J. Sutton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 7

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:clustering· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:human· 2

Frequent Co-Authors

I. A. Cockburn· 6 shared A. H. Idris· 3 shared D. Chatterjee· 3 shared H. A. McNamara· 3 shared R. A. Seder· 3 shared X. Gao· 3 shared Y. Cai· 3 shared C. J. Jackson· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersImmunology

I. A. Cockburn

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Author profile →

7 papers

Recent·Most cited

Plasma cells are formed in waning germinal centers via an affinity-independent process

H. J. Sutton, B. J. Parker, M. Lofgren, C. Dacon, D. Chatterjee, X. Gao, H. G. Kelly, R. A. Seder, J. Tan, A. H. Idris, T. Neeman, I. A. Cockburn

The paper tracks Ighg2A10 cells in germinal centers using single-cell RNA-seq and finds that plasma cells form in waning GCs through an affinity-independent process.

bioRxiv · Apr 13, 2023 · PreprintImmunology

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

J. H. Lee, H. J. Sutton, C. A. Cottrell, I. Phung, G. Ozorowski, L. M. Sewall, R. Nedellec, C. Nakao, M. Silva, S. T. Richey, J. L. Torres, W.-H. Lee, E. Georgeson, M. Kubitz, S. Hodges, , S. Crotty

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

bioRxiv · Dec 20, 2021 · PreprintImmunology

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

B. Boast, K. Helian, D. Andrews, X. Li, V. Cho, A. Closa, H. J. Sutton, J. H. Reed, H. Bergmann, C. M. Roots, M. Yabas, N. Barthel, S. A. Omari, C. Young, L. A. Miosge, , A. Enders

Reduced PAX5 function in mice leads to uncommitted B cell development and B-ALL with secondary mutations in Jak3 and Ptpn11.

bioRxiv · Jan 29, 2021 · PreprintImmunology

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

H. J. Sutton, R. Aye, A. H. Idris, R. Vistein, E. Nduati, O. Kai, J. Mwacharo, L. Xi, X. Gao, D. Andrews, M. Koutsakos, T. H. O. Nguyen, M. Nekrasov, P. Milburn, A. Ethala, , I. A. Cockburn

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

bioRxiv · May 28, 2020 · PreprintImmunology

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

F. J. Lewis, D. Chatterjee, J. Kaczmarski, X. Gao, Y. Cai, H. A. McNamara, H. J. Sutton, C. J. Jackson, I. A. Cockburn

The paper shows that B cells avidly bind to the Plasmodium CSP repeat domain, suppressing responses to protective epitopes, and that truncated CSP molecules induce broader immune responses and better protection.

bioRxiv · Jan 12, 2020Immunology

Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses

H. A. McNamara, A. H. Idris, H. J. Sutton, B. J. Flynn, Y. Cai, K. Wiehe, K. E. Lyke, D. Chatterjee, N. KC, S. Chakravarty, K. L. Sim, S. L. Hoffman, M. Bonsignori, R. A. Seder, I. A. Cockburn

The paper shows antibody feedback limits memory B cell expansion but allows diversification of vaccine-induced antibody responses by suppressing dominant epitopes while enabling subdominant ones.

bioRxiv · Oct 18, 2019 · PreprintImmunology

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

C. R. Fisher, H. J. Sutton, J. A. Kaczmarski, H. A. McNamara, B. Clifton, J. Mitchell, Y. Cai, J. N. Dups, N. J. D'Arcy, M. Singh, A. Chuah, T. Peat, C. J. Jackson, I. A. Cockburn

The paper investigates how T-dependent B cells produce antibodies that form a high-avidity multivalent complex with Plasmodium falciparum CSP, revealing structural and immunological insights.

bioRxiv · Jun 13, 2017Immunology