Author

H. A. McNamara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

I. A. Cockburn· 4 shared Y. Cai· 4 shared H. J. Sutton· 3 shared C. J. Jackson· 2 shared D. Chatterjee· 2 shared A. Chuah· 1 shared A. H. Idris· 1 shared B. Clifton· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersImmunology

I. A. Cockburn

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4 papers

Recent·Most cited

Platelets are dispensable for the ability of CD8+ T cells to accumulate, patrol, kill and reside in the liver

J. H. O'Connor, H. A. McNamara, Y. Cai, L. A. Coupland, E. E. Gardiner, C. R. Parish, B. J. McMorran, V. V. Ganusov, I. A. Cockburn

This study shows that platelets are not essential for CD8+ T cell accumulation, patrolling, killing, and residency in the liver, while ASGP-expressing cells are retained in the liver but lost from the spleen.

bioRxiv · Nov 9, 2021 · PreprintImmunology

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

F. J. Lewis, D. Chatterjee, J. Kaczmarski, X. Gao, Y. Cai, H. A. McNamara, H. J. Sutton, C. J. Jackson, I. A. Cockburn

The paper shows that B cells avidly bind to the Plasmodium CSP repeat domain, suppressing responses to protective epitopes, and that truncated CSP molecules induce broader immune responses and better protection.

bioRxiv · Jan 12, 2020Immunology

Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses

H. A. McNamara, A. H. Idris, H. J. Sutton, B. J. Flynn, Y. Cai, K. Wiehe, K. E. Lyke, D. Chatterjee, N. KC, S. Chakravarty, K. L. Sim, S. L. Hoffman, M. Bonsignori, R. A. Seder, I. A. Cockburn

The paper shows antibody feedback limits memory B cell expansion but allows diversification of vaccine-induced antibody responses by suppressing dominant epitopes while enabling subdominant ones.

bioRxiv · Oct 18, 2019 · PreprintImmunology

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

C. R. Fisher, H. J. Sutton, J. A. Kaczmarski, H. A. McNamara, B. Clifton, J. Mitchell, Y. Cai, J. N. Dups, N. J. D'Arcy, M. Singh, A. Chuah, T. Peat, C. J. Jackson, I. A. Cockburn

The paper investigates how T-dependent B cells produce antibodies that form a high-avidity multivalent complex with Plasmodium falciparum CSP, revealing structural and immunological insights.

bioRxiv · Jun 13, 2017Immunology