Filamentous aggregates are fragmented by the proteasome holoenzyme
R. Cliffe, J. C. Sang, F. Kundel, D. Finley, D. Klenerman, Y. Ye
This study shows the proteasome holoenzyme fragments amyloid fibrils into smaller, more toxic species, suggesting a novel degradation mechanism for filamentous aggregates.
bioRxiv · Nov 9, 2018Biophysics