R. Cliffe

ThX - A next-generation probe for the early detection of amyloid aggregates

This paper introduces ThX, a new fluorescent probe for detecting amyloid aggregates, showing improved brightness and binding affinity over ThT.

Filamentous aggregates are fragmented by the proteasome holoenzyme

This study shows the proteasome holoenzyme fragments amyloid fibrils into smaller, more toxic species, suggesting a novel degradation mechanism for filamentous aggregates.