Identification of a chemical probe for lipid kinase phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ)
D. H. Drewry, F. M. Potjewyd, J. L. Smith…·A. D. Axtman
This paper identifies a chemical probe for PI5P4Kγ, demonstrating its selectivity and cellular activity, and shows it activates mTORC1 signaling in breast cancer cells.