M. B. Major

A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.

SETD2 maintains nuclear lamina stability to safeguard the genome

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC

This paper develops a targeted proteomics assay to quantify NRF2 pathway components and clinical biomarkers in HNSCC, identifying correlations between NRF2 activity, HPV infection, and immune markers.

Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling

This study identifies unique roles for CK1γ3 in WNT signaling through proximity biotinylation, functional assays, and inhibitor testing, showing its distinct activation of β-catenin and Notch pathways.

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.

The ubiquitylome of developing cortical neurons

This study identifies ubiquitylated substrates of TRIM9 and TRIM67 in developing cortical neurons using ubiquitin remnant profiling.

PKIS Deep Dive Yields a Chemical Starting Point for Dark Kinases and a Cell Active BRSK2 Inhibitor

The paper investigates GW296115, a PKIS compound, showing it inhibits six dark kinases, including BRSK2, with IC50 values under 100nM and demonstrates cell activity.

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

The paper predicts APC/C substrates in silico, identifies chromatin regulators as substrates, and shows their cell cycle-dependent degradation and impact on DNA methylation.

TRIM67 Regulates Exocytic Mode and Neuronal Morphogenesis via SNAP47

The paper identifies four exocytic fusion modes in developing neurons and shows TRIM67 promotes FVF-like exocytosis by limiting SNAP47 incorporation into SNARE complexes.

Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

The paper identifies BRSK2 as a negative regulator of NRF2 by inhibiting protein synthesis through mTOR downregulation, suggesting it as a potential therapeutic target for NRF2-related diseases.

The MyMOMA domain of MYO19 encodes for distinct Miro-dependent and Miro-independent mechanisms of interaction with mitochondrial membranes

This study identifies distinct Miro-dependent and Miro-independent mechanisms by which MYO19 interacts with mitochondrial membranes through its MyMOMA domain.

Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition

This paper identifies ponatinib as a potent treatment for SCCOHT by inhibiting multiple kinases in preclinical models.