CD4+ Trm sustain the chronic phase of auto-immune neuroinflammatory disease
A. Pignata, D. Frieser, C.-C. Hsiao, H. J. Engelenburg, M. Alis, C. Gonzalez-Fierro, V. Cazaentre, R. Miranda-Capet, E. Dufourd, T. Vermeulen, A. Aida, K. Vangisbergen, N. Blanchard, J. Hamann, J. Smolders, , F. Masson
This study identifies CD4+ Trm cells in the CNS of PMS patients and EAE models, showing their role in sustaining chronic inflammation and suggesting targeting them for new therapies.
bioRxiv · Mar 26, 2024Immunology