S. Rooijakkers

Antibody-drug conjugates to treat bacterial biofilms

This paper develops antibody-drug conjugates that kill bacteria in biofilms and in vivo, showing superior antimicrobial effects compared to standard antibiotics.

Polyfunctional pathogen-specific CD4+ T cells reside in the lungs and tumors of NSCLC patients

The paper identifies polyfunctional pathogen-specific CD4+ T cells in lung and NSCLC tumor tissues, highlighting their potential for vaccine design and anti-tumor immunity.

Promoting Fc-Fc interactions between anti-capsular antibodies provides strong complement-dependent immune protection against Streptococcus pneumoniae

This paper shows that modifying anti-capsular antibodies to enhance hexamerization improves complement activation and immune protection against Streptococcus pneumoniae.

Molecular features underlying Pseudomonas aeruginosa persistence in human plasma

This study identifies molecular factors enabling Pseudomonas aeruginosa persistence in human plasma by analyzing genetic determinants and immune interactions.

In vitro evolution of colistin resistance in the Klebsiella pneumoniae complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristics.

This study shows that Klebsiella pneumoniae complex strains can develop colistin resistance through multiple evolutionary paths, with variable effects on fitness and virulence.