F. Miya

Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors mediate marked visual restoration

The paper develops an AAV-based genome editing platform to replace mutations in retinal neurons, achieving significant visual restoration in blind mice.

Quantification of multicellular colonization in tumor metastasis using exome sequencing data

The paper quantifies founder cell population size in metastatic tumors using exome sequencing data from primary and metastatic samples, finding multi-cellular origins with founder sizes ranging from 3 to 15 cells.