Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active against Multi-drug resistant Tuberculosis
Y. Dashti, F. Mohammadipanah, M. J. Belousoff, A. Vocat, D. Zabala, C. D. Fage, I. Romero-Canelon, B. Bunk, C. Sproer, J. Overmann, S. T. Cole, G. L. Challis
This study discovers two novel polyglycosylated thiopeptides, persiathiacins A and B, active against drug-resistant tuberculosis and identifies their biosynthetic gene cluster.
bioRxiv · Oct 24, 2021 · PreprintMicrobiology