Author

S. T. Cole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Vocat· 2 shared J. Piton· 2 shared A. Benjak· 1 shared A. Dux· 1 shared A. Lupien· 1 shared A. R. Said· 1 shared A. Regalla· 1 shared B. Bunk· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

A. Vocat

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active against Multi-drug resistant Tuberculosis

Y. Dashti, F. Mohammadipanah, M. J. Belousoff, A. Vocat, D. Zabala, C. D. Fage, I. Romero-Canelon, B. Bunk, C. Sproer, J. Overmann, S. T. Cole, G. L. Challis

This study discovers two novel polyglycosylated thiopeptides, persiathiacins A and B, active against drug-resistant tuberculosis and identifies their biosynthetic gene cluster.

bioRxiv · Oct 24, 2021 · PreprintMicrobiology

Leprosy in wild chimpanzees

K. J. Hockings, B. Mubemba, C. Avanzi, K. Pleh, A. Dux, E. Bersacola, J. Bessa, M. Ramon, S. Metzger, L. V. Patrono, J. E. Jaffe, A. Benjak, C. J. Bonneaud, P. Busso, E. Couacy-Hymann, , F. H. Leendertz

The paper reports leprosy-like lesions in wild chimpanzees and identifies M. leprae strains with rare genotypes, suggesting multiple introductions from an unknown source.

bioRxiv · Nov 10, 2020Evolutionary Biology

Polarly localized EccE1is required for ESX-1 function and stabilization of ESX-1 membrane proteins in Mycobacterium tuberculosis

P. Soler-Arnedo, C. Sala, M. Zhang, S. T. Cole, J. Piton

This study identifies EccE1 as a critical membrane protein required for ESX-1 function and stabilization of ESX-1 membrane proteins in Mycobacterium tuberculosis, with deletion of eccE1 reducing levels of other ESX-1 components and attenuating bacterial virulence.

bioRxiv · Oct 30, 2019Microbiology

Structure-based drug design and characterization of sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from Mycobacterium tuberculosis

J. Piton, A. Vocat, A. Lupien, C. S.-Y. Foo, O. Riabova, V. Makarov, S. T. Cole

The paper designs and characterizes sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from M. tuberculosis, finding they have improved solubility but lower activity than MCZ.

bioRxiv · Apr 10, 2018Pharmacology & Toxicology