Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae
E. Ramos Sevillano, G. Ercoli, M. Betts, J. A. Guerra-Assuncao, F. Partridge, V. Silva Entrudo Fernandes, E. Wall, S. Gordon, D. S. Ferreira, R. Heyderman, J. S. Brown
This study shows that one-carbon metabolism is essential for Streptococcus pneumoniae virulence, while proline biosynthesis has a strain-dependent role in systemic infection.
bioRxiv · Aug 3, 2023 · PreprintMicrobiology