J. S. Brown

Evolutionary double-bind treatment using radiotherapy and NK cell-based immunotherapy in prostate cancer

This study combines radiotherapy and NK cell immunotherapy to exploit an evolutionary double-bind strategy in prostate cancer, showing that RT-resistant cells become more vulnerable to NK cell killing.

Cell Types or Cell States? An Investigation of Adrenergic and Mesenchymal Cell Phenotypes in Neuroblastoma

The paper investigates whether adrenergic and mesenchymal phenotypes in neuroblastoma represent distinct cell types or dynamic cell states through theoretical modeling and hypothesis testing.

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae

This study investigates how pneumococcal lipoproteins mediate epithelial microinvasion and finds that differential lipoprotein repertoires do not significantly impact microinvasion, suggesting post-translational modifications may be responsible.

Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae

This study shows that one-carbon metabolism is essential for Streptococcus pneumoniae virulence, while proline biosynthesis has a strain-dependent role in systemic infection.

P bodies coat germ granules to promote transgenerational gene silencing in C. elegans

This study shows P body factors coat germ granules in C. elegans to enable transgenerational gene silencing by maintaining small RNA factors and secondary small RNA amplification.

GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance

This study shows that GLH/VASA helicases are essential for forming germ granules, which ensure accurate piRNA-mediated transcriptome surveillance by distinguishing self from non-self.

Improving Mathematical Models of Cancer throughGame-Theoretic Modelling: A Study in Non-SmallCell Lung Cancer

This study applies a game-theoretic model to 590 Non-Small Cell Lung Cancer patients, showing it better fits tumor dynamics than classical models and predicts treatment outcomes.

Female choice can explain the fertilization pattern in oaks

The paper tests a female choice hypothesis for oak fertilization patterns, showing that maternal diversity indices fit the model better than random ovule selection.

Intraspecific Competition and the Promotion of Ecological Specialization

This study presents a game-theoretic model showing that intraspecific competition can promote ecological specialization under specific conditions, contradicting the competitive diversification hypothesis.

Coordination games in cancer

This paper introduces a model of cancer progression based on coordination games, exploring their potential in understanding and treating cancer.

A Markov chain model of cancer treatment

This paper develops a Markov chain model to optimize cancer treatment strategies by maximizing discounted expected quality of life years, considering patient preferences and treatment timing.

Cycling hypoxia selects for constitutive HIF stabilization

The paper develops a mathematical model showing that rapid oxygen fluctuations favor pseudohypoxia by selecting for constitutive HIF stabilization despite reduced cell fitness.

Understanding the potential benefits of adaptive therapy for metastatic melanoma

This study develops mathematical models to predict adaptive therapy benefits for metastatic melanoma, showing potential delays in progression by 6-25 months compared to continuous therapy.

De Novo Discovery of High Affinity Peptide Binders for the SARS-CoV-2 Spike Protein

This paper identifies high-affinity peptide binders for the SARS-CoV-2 spike protein using affinity selection-mass spectrometry, with nanomolar affinities and selectivity over human serum proteins.

Unstable Population Dynamics in Obligate Co-Operators

This paper models population dynamics of obligate co-operators, showing that stable group dynamics lead to unstable population dynamics and eventual group collapse.

High school Internship Program in Integrated Mathematical Oncology (HIP IMO) - five-year experience at Moffitt Cancer Center

The paper describes a high school internship program in mathematical oncology, detailing its structure, curriculum, and outcomes over five years.

What is the storage effect, why should it occur in cancers, and how can it inform cancer therapy?

The paper explores the storage effect as a mechanism for intratumor heterogeneity, arguing that it may explain cancer diversity and inform therapy.

Frequency-dependent interactions determine outcome of competition between two breast cancer cell lines

This study shows that competition between two breast cancer cell lines depends on frequency-dependent interactions, not just growth rates or carrying capacities.

Non-Equilibrial Evolutionary Dynamics in Undersaturated Communities

This study analyzes how community saturation affects evolutionary dynamics in predator-prey and competition models, showing that under-saturation leads to instability and non-equilibrial behavior.

Germline RNA helicases couple RNA binding to P granule assembly at nuclear periphery

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.

Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

Using Biogeography to Assess Key Adaptation Strength in Two Bird Families

This study compares the biogeography of two nectarivorous bird families to assess the strength of their key adaptations, finding that hummingbirds occupy more extreme environments.

Both the inflammatory response and clinical outcome differ markedly between adults with pneumococcal and meningococcal meningitis in a high HIV-1 prevalent setting in sub-Saharan Africa

This study compares inflammatory responses and clinical outcomes between pneumococcal and meningococcal meningitis in HIV-high prevalence settings, finding worse outcomes in pneumococcal cases.

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.

Divergent Behavior Amid Convergent Evolution: A Case of Four Desert Rodents Learning to Respond to Known and Novel Vipers

The paper studies how four desert rodents from two deserts respond to known and novel vipers, finding that post-exposure, all rodents perceived the heat-sensing sidewinder rattlesnake as a greater risk.