Author

F. R. Simonetti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Organism:rat· 1

Frequent Co-Authors

J. D. Siliciano· 3 shared R. F. Siliciano· 3 shared F. Wu· 2 shared H. Zhang· 2 shared J. Lai· 2 shared S. G. Deeks· 2 shared A. L. Hill· 1 shared A. S. Perelson· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

J. D. Siliciano

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Author profile →

3 papers

Recent·Most cited

Cognate Antigen Engagement Induces HIV-1 Expression In CD4+ T Cells From People On Long-Term ART

M. Moskovjlevic, F. Dragoni, N. L. Board, F. Wu, J. Lai, H. Zhang, J. R. White, R. Ho, K. Lynn, P. Tebas, K. Mounzer, S. G. Deeks, L. J. Montaner, J. D. Siliciano, F. R. Simonetti, R. F. Siliciano

The paper shows that cognate antigen engagement in CD4+ T cells on long-term ART increases HIV-1 transcription through T cell activation, suggesting a role in viral rebound.

bioRxiv · Feb 27, 2024 · PreprintImmunology

Last in first out: SIV proviruses seeded later in infection are harbored in short-lived CD4+ T cells

N. Sambaturu, E. J. Fray, F. Wu, C. Zitzmann, F. R. Simonetti, D. H. Barouch, J. D. Siliciano, R. F. Siliciano, R. M. Ribeiro, A. S. Perelson, C. Molina-Paris, T. Leitner

The paper models SIV provirus divergence in CD4+ T cells, finding that short-lived cells harbor more diverged virus, while long-lived cells contain less diverged virus, explaining contradictory prior results on reservoir timing.

bioRxiv · Nov 3, 2023 · PreprintMicrobiology

Antigen-driven clonal selection shapes the persistence of HIV-1 infected CD4+ T cells in vivo

F. R. Simonetti, H. Zhang, G. P. Soroosh, J. Duan, K. Rhodehouse, A. L. Hill, S. A. Beg, K. McCormick, H. Raymond, C. L. Nobles, J. Everett, K. J. Kwon, J. A. White, J. Lai, J. B. Margolick, , R. F. Siliciano

This study links antigen responsiveness, proviral sequences, integration sites, and TCRβ sequences to show antigen-driven clonal selection maintains HIV-1 persistence in CD4+ T cells.

bioRxiv · Dec 1, 2020Microbiology