Author

J. D. Siliciano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

F. R. Simonetti· 2 shared J. Lai· 2 shared R. F. Siliciano· 2 shared R. Hoh· 2 shared S. G. Deeks· 2 shared A. L. Hill· 1 shared A. S. Perelson· 1 shared C. L. Nobles· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

F. R. Simonetti

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Author profile →

3 papers

Recent·Most cited

Last in first out: SIV proviruses seeded later in infection are harbored in short-lived CD4+ T cells

N. Sambaturu, E. J. Fray, F. Wu, C. Zitzmann, F. R. Simonetti, D. H. Barouch, J. D. Siliciano, R. F. Siliciano, R. M. Ribeiro, A. S. Perelson, C. Molina-Paris, T. Leitner

The paper models SIV provirus divergence in CD4+ T cells, finding that short-lived cells harbor more diverged virus, while long-lived cells contain less diverged virus, explaining contradictory prior results on reservoir timing.

bioRxiv · Nov 3, 2023 · PreprintMicrobiology

Antigen-driven clonal selection shapes the persistence of HIV-1 infected CD4+ T cells in vivo

F. R. Simonetti, H. Zhang, G. P. Soroosh, J. Duan, K. Rhodehouse, A. L. Hill, S. A. Beg, K. McCormick, H. Raymond, C. L. Nobles, J. Everett, K. J. Kwon, J. A. White, J. Lai, J. B. Margolick, , R. F. Siliciano

This study links antigen responsiveness, proviral sequences, integration sites, and TCRβ sequences to show antigen-driven clonal selection maintains HIV-1 persistence in CD4+ T cells.

bioRxiv · Dec 1, 2020Microbiology

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size

D. I. S. Rosenbloom, P. Bacchetti, M. Stone, X. Deng, R. J. Bosch, D. D. Richman, J. D. Siliciano, J. W. Mellors, S. G. Deeks, R. G. Ptak, R. Hoh, S. M. Keating, M. Dimapasoc, M. Massanella, J. Lai, , Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group

This study assesses the precision and repeatability of HIV-1 latent reservoir size measurements using QVOA across labs and storage conditions, finding assay variability and supporting frozen storage.

bioRxiv · Jun 6, 2018Microbiology