Extravascular spaces are the primary reservoir of antigenic diversity in Trypanosoma brucei infection
A. Beaver, Z. Keneskhanova, R. O. Cosentino, B. L. Weiss, E. O. Awuoche, G. M. Smallenberger, G. Y. Buenconsejo, N. P. Crilly, J. E. Smith, J. M. Hakim, B. Zhang, B. Bobb, F. Rijo-Ferreira, L. M. Figueiredo, S. Aksoy, , M. R. Mugnier
The paper shows that extravascular spaces, not the bloodstream, are the main source of antigenic diversity in Trypanosoma brucei infections, with over 75% of VSGs found exclusively in these spaces.
bioRxiv · Jun 27, 2022Microbiology