Author

M. R. Mugnier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

J. E. Smith· 3 shared J. M. Hakim· 3 shared J. So· 3 shared B. Zhang· 2 shared Chagas working group· 2 shared R. H. Gilman· 2 shared R. O. Cosentino· 2 shared T. N. Siegel· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

J. E. Smith

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

High-resolution scRNA-seq reveals genomic determinants of antigen expression hierarchy in African Trypanosomes

K. R. McWilliam, Z. Keneskhanova, R. O. Cosentino, A. Dobrynin, J. E. Smith, I. Subota, M. R. Mugnier, M. Colome-Tatche, T. N. Siegel

This study uses high-resolution scRNA-seq to uncover how genomic rearrangements during antigen switching in Trypanosoma brucei depend on repair mechanisms and homologous templates.

bioRxiv · Mar 22, 2024 · PreprintMicrobiology

DNA damage drives antigen diversification through mosaic VSG formation in Trypanosoma brucei

J. E. Smith, K. J. Wang, E. M. Kennedy, J. M. Hakim, J. So, A. K. Beaver, A. Magesh, S. D. Gilligan-Steinberg, J. Zheng, B. Zhang, D. N. Moorthy, E. H. Akin, L. Mwakibete, M. R. Mugnier

The paper demonstrates that DNA damage induces VSG recombination in T. brucei, leading to antigenic variation and immune evasion.

bioRxiv · Mar 22, 2024Microbiology

Immunologic changes are detectable in the peripheral blood transcriptome of clinically asymptomatic Chagas cardiomyopathy patients

C. Duque, J. So, Y. E. Castro-Sesquen, K. DeToy, S. A. G. Guarnizo, F. Jahanbakhsh, E. M. Machaca, M. Miranda-Schaeubinger, I. Chakravarti, V. Cooper, M. E. Schmidt, A. Luigi, R. Marcus, K. R. Talaat, R. H. Gilman, , Chagas working group

This study identifies immune-related gene expression changes in asymptomatic Chagas cardiomyopathy patients, suggesting unique immune mechanisms in early disease progression.

bioRxiv · Oct 3, 2023Immunology

Amplicon sequencing reveals complex infection in infants congenitally infected with Trypanosoma cruzi and informs the dynamics of parasite transmission

J. M. Hakim, A. Waltmann, F. Tinajeros, O. Kharabora, E. Malaga Machaca, M. Calderon, M. d. C. Menduina, J. Wang, D. Rueda, M. Zimic, M. Verastegui, J. J. Juliano, R. H. Gilman, M. R. Mugnier, N. M. Bowman, Chagas working group

The paper uses amplicon sequencing to analyze parasite strain diversity in mothers and infants infected with Trypanosoma cruzi, finding multiple strains in some individuals and increased diversity in infants post-birth.

bioRxiv · Nov 16, 2022Microbiology

Extravascular spaces are the primary reservoir of antigenic diversity in Trypanosoma brucei infection

A. Beaver, Z. Keneskhanova, R. O. Cosentino, B. L. Weiss, E. O. Awuoche, G. M. Smallenberger, G. Y. Buenconsejo, N. P. Crilly, J. E. Smith, J. M. Hakim, B. Zhang, B. Bobb, F. Rijo-Ferreira, L. M. Figueiredo, S. Aksoy, , M. R. Mugnier

The paper shows that extravascular spaces, not the bloodstream, are the main source of antigenic diversity in Trypanosoma brucei infections, with over 75% of VSGs found exclusively in these spaces.

bioRxiv · Jun 27, 2022Microbiology

VSGs expressed during natural T. b. gambiense infection exhibit extensive sequence divergence and a subspecies-specific expression bias

J. So, S. Sudlow, A. Sayeed, T. Grudda, S. Deborggraeve, D. M. Ngoyi, D. K. Desamber, B. Wickstead, V. Lejon, M. R. Mugnier

This study identifies VSG expression patterns in T. b. gambiense infections, revealing subspecies-specific biases and sequence divergence.

bioRxiv · Sep 9, 2021Microbiology