Author

J. M. Hakim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

M. R. Mugnier· 3 shared B. Zhang· 2 shared J. E. Smith· 2 shared A. Beaver· 1 shared A. K. Beaver· 1 shared A. Magesh· 1 shared A. Waltmann· 1 shared B. Bobb· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

M. R. Mugnier

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3 papers

Recent·Most cited

DNA damage drives antigen diversification through mosaic VSG formation in Trypanosoma brucei

J. E. Smith, K. J. Wang, E. M. Kennedy, J. M. Hakim, J. So, A. K. Beaver, A. Magesh, S. D. Gilligan-Steinberg, J. Zheng, B. Zhang, D. N. Moorthy, E. H. Akin, L. Mwakibete, M. R. Mugnier

The paper demonstrates that DNA damage induces VSG recombination in T. brucei, leading to antigenic variation and immune evasion.

bioRxiv · Mar 22, 2024Microbiology

Amplicon sequencing reveals complex infection in infants congenitally infected with Trypanosoma cruzi and informs the dynamics of parasite transmission

J. M. Hakim, A. Waltmann, F. Tinajeros, O. Kharabora, E. Malaga Machaca, M. Calderon, M. d. C. Menduina, J. Wang, D. Rueda, M. Zimic, M. Verastegui, J. J. Juliano, R. H. Gilman, M. R. Mugnier, N. M. Bowman, Chagas working group

The paper uses amplicon sequencing to analyze parasite strain diversity in mothers and infants infected with Trypanosoma cruzi, finding multiple strains in some individuals and increased diversity in infants post-birth.

bioRxiv · Nov 16, 2022Microbiology

Extravascular spaces are the primary reservoir of antigenic diversity in Trypanosoma brucei infection

A. Beaver, Z. Keneskhanova, R. O. Cosentino, B. L. Weiss, E. O. Awuoche, G. M. Smallenberger, G. Y. Buenconsejo, N. P. Crilly, J. E. Smith, J. M. Hakim, B. Zhang, B. Bobb, F. Rijo-Ferreira, L. M. Figueiredo, S. Aksoy, , M. R. Mugnier

The paper shows that extravascular spaces, not the bloodstream, are the main source of antigenic diversity in Trypanosoma brucei infections, with over 75% of VSGs found exclusively in these spaces.

bioRxiv · Jun 27, 2022Microbiology