Author

F. Roca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

L. Ramakrishnan· 2 shared A. J. Pagan· 1 shared D. Tobin· 1 shared G. Thwaites· 1 shared L. Whitworth· 1 shared M. Troll· 1 shared N. D. Bang· 1 shared N. H. Phu· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

L. Ramakrishnan

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2 papers

Recent·Most cited

Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone

L. Whitworth, R. Troll, A. J. Pagan, F. Roca, P. H. Edelstein, M. Troll, D. Tobin, N. H. Phu, N. D. Bang, G. Thwaites, N. T. Thuong Thuong, R. Sewell, L. Ramakrishnan

The paper examines how pre-treatment CSF cytokine levels influence survival in dexamethasone-treated tuberculous meningitis, finding higher cytokine levels correlate with better survival.

bioRxiv · Nov 23, 2020Immunology

Tumor Necrosis Factor induces pathogenic programmed macrophage necrosis in tuberculosis through a mitochondrial-lysosomal-endoplasmic reticulum circuit

F. Roca, S. Redmond, L. Ramakrishnan

This study shows that TNF induces macrophage necrosis in tuberculosis via a mitochondrial-lysosomal-endoplasmic reticulum circuit involving ROS, ceramide, and calcium overload.

bioRxiv · Jan 3, 2019Cell Biology