Author

A. J. Pagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Organism:zebrafish· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

L. Ramakrishnan· 5 shared J. K. Shanahan· 2 shared M. M. Osman· 2 shared C. B. Moens· 1 shared D. M. Tobin· 1 shared D. Tobin· 1 shared E. L. Pearce· 1 shared E. M. Busch-Nentwich· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersImmunology

L. Ramakrishnan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

mTOR-regulated Mitochondrial Metabolism Limits Mycobacterium-induced Cytotoxicity

A. J. Pagan, L. J. Lee, J. Edwards-Hicks, C. B. Moens, D. M. Tobin, E. M. Busch-Nentwich, E. L. Pearce, L. Ramakrishnan

This study identifies mTOR as a host factor that protects macrophages from Mycobacterium-induced death by regulating mitochondrial metabolism.

Cell · Sep 1, 2022Peer-reviewedImmunology

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence

M. M. Osman, J. K. Shanahan, F. Chu, K. Takaki, M. Pinckert, A. J. Pagan, R. Brosch, W. Conrad, L. Ramakrishnan

This paper identifies conserved residues in the C-terminal tail of ESAT-6 required for phagosomal damage and virulence, while showing that secretion levels remain near-normal in these mutants.

bioRxiv · Jan 14, 2022Microbiology

Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone

L. Whitworth, R. Troll, A. J. Pagan, F. Roca, P. H. Edelstein, M. Troll, D. Tobin, N. H. Phu, N. D. Bang, G. Thwaites, N. T. Thuong Thuong, R. Sewell, L. Ramakrishnan

The paper examines how pre-treatment CSF cytokine levels influence survival in dexamethasone-treated tuberculous meningitis, finding higher cytokine levels correlate with better survival.

bioRxiv · Nov 23, 2020Immunology

Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage

M. M. Osman, L. Ramakrishnan, A. J. Pagan, J. K. Shanahan

This study shows PDIMs in M. marinum enhance phagosomal membrane damage and hemolysis, with PDIM mutants retaining more membrane-damaging activity than ESX-1 mutants.

bioRxiv · May 4, 2020Microbiology

Schistosoma mansoni eggs modulate the timing of granuloma formation to promote transmission

K. K. Takaki, G. Rinaldi, M. Berriman, A. J. Pagan, L. Ramakrishnan

This study shows that Schistosoma mansoni eggs modulate granuloma formation timing to promote parasite transmission by evading immune response until optimal extrusion.

bioRxiv · Apr 14, 2020Immunology