Biosynthesis of Isonitrile Lipopeptides by Conserved Non-ribosomal Peptide Synthetase Gene Clusters in Actinobacteria
N. C. Harris, M. Sato, N. A. Herman, F. Twigg, W. Cai, J. Liu, J. Downey, R. Khalaf, J. Martin, H. Koshino, W. Zhang
The paper identifies a conserved gene cluster in Actinobacteria that synthesizes isonitrile lipopeptides (INLPs) via a unique thio-template mechanism and links it to metal transport in Mycobacterium marinum.
bioRxiv · Mar 27, 2017Biochemistry