Author

J. Downey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Pernet· 1 shared F. Twigg· 1 shared H. E. Randolph· 1 shared H. Koshino· 1 shared I. L. King· 1 shared J. Liu· 1 shared J. Martin· 1 shared K. A. Tran· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

E. Pernet

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2 papers

Recent·Most cited

Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus

J. Downey, H. E. Randolph, E. Pernet, K. A. Tran, S. A. Khader, I. L. King, L. B. Barriero, M. Divangahi

This study shows that mitochondrial cyclophilin D promotes disease tolerance against influenza virus by supporting NK cell development and IL-22 production, reducing lung damage.

bioRxiv · May 28, 2021Immunology

Biosynthesis of Isonitrile Lipopeptides by Conserved Non-ribosomal Peptide Synthetase Gene Clusters in Actinobacteria

N. C. Harris, M. Sato, N. A. Herman, F. Twigg, W. Cai, J. Liu, J. Downey, R. Khalaf, J. Martin, H. Koshino, W. Zhang

The paper identifies a conserved gene cluster in Actinobacteria that synthesizes isonitrile lipopeptides (INLPs) via a unique thio-template mechanism and links it to metal transport in Mycobacterium marinum.

bioRxiv · Mar 27, 2017Biochemistry