PhysiologybioRxiv
Enhanced CICR activity reduces ER Ca2+ level in cells expressing CPVT-linked mutant RyR2
N. Kurebayashi, T. Murayama, R. Ohta…·T. Sakurai
This paper quantitatively examines how CPVT-linked RyR2 mutations affect ER Ca2+ release threshold by measuring CICR activity and simulating cellular responses.
DOI 10.1085/jgp.202112869